Publications

Published research outputs

On this page you can access links to published research outputs from the ARK hospital research which contain detailed information about the intervention, its development and implementation.

Why do hospital prescribers continue antibiotics when it is safe to stop? Results of a choice experiment survey

BMC Medicine

Antibiotic treatment guidelines that conflict with antibiotic discontinuation (e.g. pre-specify fixed durations) may discourage safe discontinuation at prescription review

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Overview of systematic reviews assessing the evidence for shorter versus longer duration antibiotic treatment for bacterial infections in secondary care

PLOS One

Assessment of the evidence for effectiveness of shorter-duration antibiotic treatment

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It’s time to put a hard stop to antibiotic overprescribing in hospitals

thebmjopiinion

ARK champions argue that empiric antibiotic treatment should be time limited and only continued beyond scheduled review if definitive antibiotic treatment is clearly indicated

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The antibiotic course has had its day

BMJ

Decisions around antibiotic treatment duration should be personalised for individual patients rather than driven by unevidenced syndrome-specific course durations

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Antibiotic review kit for hospitals (ARK-Hospital): a stepped-wedge cluster-randomised controlled trial

Lancet Infectious Diseases

Implementation of the ARK toolkit resulted in sustained reductions in antibiotic use among adult acute general medical inpatients

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Patient engagement with antibiotic messaging in secondary care: a qualitative feasibility study of the ‘review and revise’ experience

Pilot and Feasibility Studies

Patient information and involvement in antibiotic prescription reviews support healthcare professionals to safely reduce antibiotic use through prescription review and revise

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Adaptation and implementation of the ARK (Antibiotic Review Kit) intervention to safely and substantially reduce antibiotic use in hospitals: a feasibility study

Journal of Hospital Infection

ARK provides a feasible and acceptable mechanism to support stopping antibiotics safely at post-prescription reviews in an acute hospital setting

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Intervention planning for Antibiotic Review Kit (ARK): a digital and behavioural intervention to safely review and reduce antibiotic prescriptions in acute and general medicine

Journal of Antimicrobial Chemotherapy

Co-design and development of the ARK tool kit using a theory-, evidence- and person-based co-design approach

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